Shop Shiseido Vital Perfection LiftDefine Radiance Serum, 2.7-oz. online at Macys.com. Discover a fresher, more youthful look in four weeks.* Experience tightening, lifting and revitalized radiance with this multi-benefit face serum that delivers quick lifting, firming and contouring results in a lightweight, non-greasy serum. Instantly, skin appears radiant and rejuvenated.